Прогрессирование энтеровирусного энцефалита у детей

Аннотация

Калит сўзлар: Мақолада энтеровирусли энцефалит билан касалланган Энтеровирусли энцефалит 35 нафар болани динамик мониторинг натижалари таҳлил Диагностика қилинган. Энтеровирус энцефалити бўлган боланинг ўртача Клиника ёши 6,04 ± 0,84 ёшни ташкил этади. Энтеровирус Даволаш Болалар энцефалитининг максимал тарқалиши август–сентябр ойларида кузатилади ва умумий энтеровирус инфекциясининг кўпайиши билан мос келади. 1 Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan E-mail: Xilola.kabirova.89@mail.ru 2 Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan Жамият ва инновациялар – Общество и инновации – Society and innovations Special Issue – 1 (2021) / ISSN 2181-1415 Прогрессирование энтеровирусного энцефалита у детей АННОТАЦИЯ Ключевые слова: В статье проведен анализ результатов динамического Энтеровирусные наблюдения за 35 детьми с энтеровирусными энцефалиты энцефалитами. Средний возраст детей, больных Диагностика энтеровирусными энцефалитами, составил 6,04±0,84 года. Клиника Лечение Максимальная заболеваемость энтеровирусными Дети энцефалитами наблюдается в августе-сентябре и совпадает с ростом общей заболеваемости энтеровирусными инфекциями. Enteroviral infection is characterized by a wide clinical polymorphism, lesion of central nerve system, gastrointestinal tract, skin and muscles. Compatibility of enteroviruses to nerve tissue provides often involvement of brain tissue and meanings into the pathological process, a great range of clinical variants, long term and severity of the disease. 65-70% of all encephalitis in children are the forms with isolated cerebral lesions [1, 4]. According to some authors the average age of the children with encephalitis varies between 4.2±1.5 and 5.5 years old [2; 3]. The basic clinical manifestations of encephalitis are consciousness impairments (86.5%) and epileptic seizures (76.9%). Together with etiological factor, vital functions, expression of common cerebral and focal symptoms these serve to be the factors determining the outcome of the disease [4-6]. The part of viruses in the etiological structure of encephalitis reaches 80-89% of all etiological factors causing the pathology [1]. Among the viral reasons of encephalitis there are enterovirus (12%), Herpes Simplex virus (5%), and cytomegalovirus (2%) [3; 6]. THE OBJECTIVE To study characteristics of epidemiology, clinical progression of encephalitis with enteroviral etiology in children at the time of therapy. RESEARCH METHODS AND DATA The research was based on the data of 35 children with viral encephalitis. The average age of the children with enteroviral encephalitis was 6.04±0.84 years old. 65.7% of all these patients were boys. Analysis of the age characteristics of enteroviral encephalitis revealed its prevalence among boys of 11-14 years old (37.5%), 6-7 years old (25%), 3-5 years old (18.8%). Among the girls there was prevalence in the following ages: 3-5 years old (41.7%) and 7- 9 years old (25%). All the children were checked in compliance with the diagnostic and therapeutic standards approved by the Ministry of Health of the RUz. RESULTS OF THE STUDY AND ITS DISCUSSION Analysis of enteroviral encephalitis morbidity rate confirmed its higher prevalence in summer and autumn seasons (74.23% of the patients), with maximal rate in August- September (54.3%). According to the observation results intra-annual dynamics of enteroviral encephalitis was as follows: December -February (11.42%), April (8.57%), May (5.71%), June (5.71%), July (8.57%), August (34.3%), September (20%), and October 146 Жамият ва инновациялар – Общество и инновации – Society and innovations Special Issue – 1 (2021) / ISSN 2181-1415 (5.71%). In March and November there were no registered patients with enteroviral encephalitis. In few cases we revealed participation of water transmission factor (5.71%) and contact with people suffering ARVD (17.1%) in the development of the disease. In our studies there was a prevalence of isolated damage of brain. Encephalomyelopolyradiculoneuritis took only 5.7% in the structure of enteroviral encephalitis. Other manifestations of enteroviral infection in these patients were hepatitis, gastroenteritis, herpetic tonsillitis, pancreatitis, exanthema the prevalence rate of which varied from 2.86 to 11.4%. Enteroviral encephalitis is characterized by acute start of the disease. At the debut encephalitis 88.6% of the patients had registered rise of temperature up to sub-febrile (38.7%) and febrile values (54.8%). Pyretic fever was observed in 6.45% of the cases. Prostration and weakness were mentioned by 60% of the patients. Neurological symptoms in the patients with enteroviral encephalitis had debut manifestation both in hyper excitability (motor dysfunctions, seizures, ICH) and symptoms of CNS suppression. Common cerebral symptoms such as variable intensity headache, dizziness (37.1%), intensive and not very intensive vomiting (34.3%), impairments of consciousness (sopor, amentia)(8.57%). Convul