MECHANISMS OF INNATE AND ADAPTIVE IMMUNITY IN CYTOMEGALOVIRUS INFECTION

Аннотация

Cytomegalovirus (CMV) is a ubiquitous herpesvirus that establishes lifelong latency in the human host. The intricate interplay between innate and adaptive immune responses is critical for controlling CMV infection and preventing viral reactivation. This study examines the mechanisms underlying both arms of the immune system in response to CMV infection. Through a combination of in vitro experiments, cytokine profiling, and immunophenotyping, we delineate the roles of natural killer (NK) cells, dendritic cells (DCs), T lymphocytes, and B lymphocytes in viral clearance. Our results indicate that early innate responses, mediated by pattern recognition receptors (PRRs) and type I interferons, set the stage for a robust adaptive response. The data presented herein—summarized in three comprehensive tables—underscore the dynamic regulation of cytokine production, cellular activation, and effector functions that collectively contribute to the host defense against CMV. These findings provide important insights that may inform the development of targeted immunotherapies forimmunocompromised individuals. Keywords: Cytomegalovirus, innate immunity, adaptive immunity, NK cells, T lymphocytes, cytokines.