COMPARISON OF VARIABILITY INDICATORS HEART RHYTHM IN WOMEN RHEUMATOID ARTHRITIS AND WOMEN WITHOUT RHEUMATIC DISEASES

Аннотация

Goal. Compare daily heart rate variability (HRV), normalized by age and average heart rate during the day (HRV) inwomen withrheumatoid arthritis (RA)and women in thecontrol group. Materials and methods. 97 patients with a reliable diagnosis of RA aged from 20 to 60 years were examined. The control group included 25 women without rheumatic diseases. In addition to the clinical manifestations, the degree of activity and severity of RA, the presence of the main traditional risk factors for cardiovascular diseases was assessed, Holter ECG monitoring (XM- ECG) was performed with automatic calculation of the frequency characteristics of the sinus rhythm of the heart, temporal and spectral parameters of HRV. In order to offset the influence of age and heart rate on HRV indicators, the initial HRV parameters were converted into their logarithms, the standardization of logarithms by age and HRV, and the calculation of the exponentfrom thestandardized logarithm. Results. The temporal and frequency indices of HRV, normalized by age and HRSS (HRSs), were significantly lower in women with RA than in the control group. A decrease in HRSp is observed in 14-24% of women with RA, while the greatest decrease was noted among the parameters characterizing the tone of the parasympathetic division of the autonomic nervous system (RMSSDn, pNN50n,HFn). Conclusion. Young and middle-aged female RA patients differ from women in the control group by a significant decrease in temporal and spectral HRV indicators, normalized by age and heart rate. Key words:rheumatoid arthritis, heart rate variability