Пациенты с хроническим заболеванием печени и COVID-19 (обзор литературы и собственные данные)

Аннотация

Калит сўзлар: COVID-19 yangi koronavirusining pandemiyasi butun COVID 19 dunyoda tibbiyotni ushbu infektsiyaga qarshi asosiy kurashga Jigar shikastlanishi o'zgartirdi. Surunkali jigar kasalliklariga chalingan bemorlar Prognoz epidemiya paytida shifokorlarning diqqatini kuchaytirilishini Jigarning surunkali kasalligi Qon kimyosi talab qiladi, chunki ularning kasalliklari kuchayishi fonida Yangi koronavirus nafaqat COVID-19 virusli infektsiyasini yuqtirish xavfi, balki infektsiyasining borishi uning og'ir yo'li ham oshadi. Jigarning jiddiy shikastlanishi bilan tasdiqlangan KOVID-19 bilan kasallangan bemorlar - yuqori biokimyoviy faollik. Ba'zi xabarlarga ko'ra, KOVID-19 ning og'ir kursi bilan og'rigan bemorlarda ALT darajasi oshadi, 1 Bukhara state medical institute. Bukhara. Uzbekistan 2 Bukhara state medical institute. Bukhara. Uzbekistan 3 Bukhara state medical institute. Bukhara. Uzbekistan Жамият ва инновациялар – Общество и инновации – Society and innovations Special Issue – 2 (2021) / ISSN 2181-1415 trombotsitlar soni kamayadi, albuminlar miqdori kamayadi va yuqori xavfga ega bo'lgan ulanish (barcha ko'rsatkichlar emas). o'lim mumkin. Пациенты с хроническим заболеванием печени и COVID-19 (обзор литературы и собственные данные) АННОТАЦИЯ Ключевые слова: Пандемия нового коронавируса COVID-19 переключила COVID 19 медицину во всем мире на первичную борьбу с этой Поражение печени инфекцией. Пациенты с хроническими заболеваниями Прогноз печени требуют повышенного внимания врачей во время Хроническое заболевание печени эпидемии, поскольку на фоне обострения их заболевания Химический анализ крови увеличивается не только риск заражения вирусной Течение новой инфекцией COVID 19, но и более тяжелое ее течение. коронавирусной Пациенты с подтвержденным COVID-19 с тяжелым инфекции поражением печени - высокая биохимическая активность. По некоторым данным, у пациентов с тяжелым течением COVID-19 наблюдается повышение уровня АЛТ, снижение количества тромбоцитов, снижение уровня альбумина и связь (хотя и не все показатели) с более высоким риском смертности возможна. THE URGENCY OF THE PROBLEM The global pandemic of the new coronavirus infection (COVID-19) caused by the SARSCoV-2 coronavirus began in Wuhan, China in December 2019 and has since spread around the world. Coronavirus infection (COVID-19) is an acute infectious disease caused by a new strain of the SARS CoV-2 coronavirus with aerosol-capillary and contact- mechanical transmission [2,4,17]. The pathogenetic COVID-19 is characterized by viremia, local and systemic immune-inflammatory processes, hyperactivity of the coagulation cascade, endothelial disease, hypoxia, which leads to the development of micro- and macrothrombosis; proceeds from asymptomatic to clinically severe forms with intoxication, fever, damage to the vascular endothelium, lungs, heart, kidneys, gastrointestinal tract, central and peripheral nervous system, system at risk [1,2,3,5,7,9,18,21]. The pandemic of the new coronavirus COVID-19 has switched medicine around the world on the primary fight against this infection. However, the COVID-19 attack did not cancel diseases that humanity suffered before the pandemic developed. And, as thanks to the joint efforts of the medical community, the pandemic is stabilizing, and in a number of countries are beginning to decline, the need is ripe to return attention to patients with other diseases and assess their interaction with the new an unprecedented infection, the features of which both per se and in combination with other pathological conditions, we still know very little [3,4,6,18]. During the pandemic, it became clear that COVID - 19 is not just acute respiratory infection, but a disease with multiple organ systemic damage, including number of such an important organ as the liver. This issue was covered by us in special reviews [3,5,6,13,15] based on a generalization of the data available at that time literature. The liver is a vital 499 Жамият ва инновациялар – Общество и инновации – Society and innovations Special Issue – 2 (2021) / ISSN 2181-1415 organ with multiple functions. The protective function of the liver includes detoxification of endogenous and exogenous factors. Liver cells are actively involved in the body's immune defense. The liver contains T- and B-lymphocytes, endothelial cells produce inflammatory mediators IL-1 and IL-6, Kupffer cells are specialized liver macrophages and are necessary for effective capture of the virus and disruption of its replication. The latter process includes an asset cation of Kupffer cells with interferon (IFN) -I and prevents the spread of the virus to neighboring hepatocytes. In the absence of Kupffer cells, hepatocytes are unable to suppress viral replication even in the presence of IFN-I, which leads to long- term viral replication and even to possible severe T-cell immunopathology [4,18,20]. It has been shown that the liver, along with the respiratory tract, is actively participates in the patholog