THE INFLUENCE OF GENETIC FACTORS ON SUSCEPTIBILITY TO TUBERCULOSIS

Аннотация

Tuberculosis (TB) remains a leading infectious cause of morbidity and mortality worldwide. Although various environmental and socioeconomic factors contribute to TB risk, a growing body of evidence highlights the importance of genetic predisposition in host susceptibility to Mycobacterium tuberculosis infection [1]. This review summarizes current knowledge of the genetic variants associated with increased or decreased TB risk, highlights emerging genomic and transcriptomic approaches, and discusses the complex interplay between host genes and pathogen- related factors [2]. Understanding these genetic determinants can facilitate personalized risk assessments, inform vaccine development, and guide novel therapeuticstrategies [3]. Keywords: tuberculosis, Mycobacteriumtuberculosis,genetics, susceptibility, immuneresponse.