UNDERSTANDING THE CLINICAL SPECTRUM OF DIABETIC POLYNEUROPATHY IN TYPE 1 DIABETES: AN IN-DEPTH ANALYSIS

Аннотация

Diabetic polyneuropathy (DPN) stands as one of the most prevalent and debilitating complications of type 1 diabetes mellitus (T1DM), significantly impacting the quality of life of affected individuals. As a chronic microvascular complication, DPN results from prolonged hyperglycemia and vascular damage, leading to dysfunction and damage of peripheral nerves. This condition manifests through a spectrum of sensory, motor, and autonomic disturbances, with symptoms ranging from numbness and tingling to pain and muscle weakness. Additionally, DPN poses a considerable risk for complications such as foot ulcers, infections, and lower limb amputations, thus underscoring its clinical significance and socioeconomic burden.