Влияние феназепама на топографию и активность энтеральных ферментов у растущих крыс в условиях иммобилизационного стресса

Аннотация

Experiments carried out on adult rats of "conventionally mixed" group, not been tested for aggression, as well as in growing rats of different ages showed that there is a definite pattern in the localization of the enzyme activity of the small intestine. Indicators of functional activity in adult rats of mixed and non-aggressive group are of the same type, but rats of the aggressive group have differences. Such identity is typical for rats aged 21 and 30 days. Depending on the behavioral characteristics, adult rats, as well as their progeny have more variable enzymatic activities topography. Immobilization stress differently affects the morphological and functional characteristics of the small intestine in adult rats according to their behavioral characteristics. In rats aged 21 days, born to parents of mixed, non-aggressive and aggressive group, immobilization stress causes similar disturbances in the functional state of the small intestine. Phenazepam better corrects violations in the functional state of the small intestine during immobilization stress in adult aggressive rats in comparing with individuals of mixed and non-aggressive groups. Prophylactic introduction of Phenazepam has almost no protective effects during immobilization stress in rats aged 21 days, regardless of the behavioral characteristics of their parents. Protective effect of a tranquilizer begins to emerge in young rats aged 30 days, especially those born from aggressive parents