EXPLORING THE ANTIOXIDANT POTENTIAL OF COSCINIUM FENESTRATUM STEM EXTRACTS IN STREPTOZOTOCIN-INDUCED TYPE 1 DIABETIC RATS: A THERAPEUTIC APPROACH

Аннотация

This study investigates the antioxidant properties of Coscinium fenestratum stem extracts in a streptozotocin-induced type 1 diabetes rat model. Diabetes mellitus is associated with oxidative stress and impaired antioxidant defense mechanisms, leading to various complications. Coscinium fenestratum, a medicinal plant rich in bioactive compounds, has shown potential antioxidant effects. In this research, type 1 diabetes was induced using streptozotocin in rats, followed by the administration of Coscinium fenestratum stem extracts. The extracts' antioxidant potential was evaluated through measurements of reactive oxygen species levels, enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase), and non-enzymatic antioxidants (glutathione, vitamin C, vitamin E). Histological assessments of pancreatic tissues were also conducted. The results demonstrate that Coscinium fenestratum extracts significantly reduce oxidative stress markers and enhance antioxidant defenses in diabetic rats. Moreover, histological improvements in pancreatic tissues were observed. These findings suggest that Coscinium fenestratum stem extracts hold promise as a therapeutic intervention for combating oxidative stress-associated complications in type 1 diabetes. KEYWORDS Coscinium fenestratum, antioxidant, streptozotocin, type 1 diabetes, oxidative stress, enzymatic antioxidants, non- enzymatic antioxidants, reactive oxygen species, pancreatic histology, therapeutic intervention.