ИММУНОЛОГИЧЕСКИЕ АСПЕКТЫ РАЗВИТИЯ ПРЕЭКЛАМПСИИ

Аннотация

Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of pregnancy, which affects 5-10% of pregnant women. This problem is especially important in developing countries, where the incidence of hypertensive pregnancy disorders is higher and maternal mortality rates are 20 times higher than in developed countries. Risk factors for PE include obesity, insulin resistance and hyperlipidemia, which stimulate the release of inflammatory cytokines and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations coincide with the development of PE is still not very clear. The associated poor trophoblast invasion and uteroplacental artery remodeling described in PE increase reactive oxygen species (ROS), hypoxia and ED.