EFFECT OF POLYPHENOLS ISOLATED FROM EUPHORBIA FRANCHETII (B.FEDTSCH) ON LPO PROCESSES IN MITOCHONDRIA

Аннотация

The production of free radicals in various tissues and cells of the body through many endogenous and exogenous pathways causes oxidative stress, which leads to the development of various diseases in humans. Therefore, the study of the antioxidant properties of biologically active substances isolated from plants is of great importance. It is known that epidemiologically, fruits and vegetables rich in antioxidants in the diet prevent the development of many diseases associated with oxidative stress. Recent studies have shown that mitochondria play an important role in apoptotic and necrotic cell death. As a result of mitochondrial dysfunction, the number of mitochondria in tissues decreases, deep ultrastructural anomalies of organelles develop, mitochondrial biogenesis is disrupted, the activity of enzyme complexes of the respiratory chain changes, and ATP synthesis is inhibited. At the same time, mitochondrial dysfunction can lead to calcium homeostasis disruption, excessive production of reactive oxygen species, as well as the transition of the megapore to an open conformation, a decrease in the expression of the antiapoptotic protein Bcl-2, the release of cytochrome c, the activation of proapoptotic caspase-3 and the DNA repair enzyme poly (-ADP ribose) polymerase. From the above, it can be seen that a specific mitochondrial dysfunction is observed in the process of lipid peroxidation (LPO) that develops during oxidative stress