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РецензированоEN2025

REPURPOSING 20-HYDROXYECDYSONE FOR CANCER THERAPY: COMPUTATIONAL EVIDENCE FOR AQUAPORIN-5 INHIBITION

M Makhamov · D Abduvokhidov · J Razzokov · A Sharipov

Евразийский журнал академических исследований · 521 · 2025

Аннотация

Aquaporin-5 (AQP5) is a membrane channel protein whose abnormal overexpression has been linked to tumor growth, migration, and metastasis in cancers such as breast, lung, and gastric carcinoma. These oncogenic roles make AQP5 an attractive therapeutic target. Natural compounds like 20-Hydroxyecdysone (ecdysterone), known for diverse biological activities, warrant investigation as potential modulators of AQP5 in cancer.

Доказательный фрагмент

«Aquaporin-5 (AQP5) is a membrane channel protein whose abnormal overexpression has been linked to tumor growth, migration, and metastasis in cancers such as breast, lung, and gastric carcinoma.»

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Демо-превью

Aquaporin-5 (AQP5) is a membrane channel protein whose abnormal overexpression has been linked to tumor growth, migration, and metastasis in cancers such as breast, lung, and gastric carcinoma. Полный текст публикации CiteX не хранит — доступ к первоисточнику открывается по DOI согласно лицензии издателя и выбранному плану.

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Узбекистан
Ключевые слова
aqp, aquaporin-, membrane, channel, protein, whose, abnormal
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