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THE PATHOPHYSIOLOGICAL MECHANISMS OF OXIDATIVE STRESS IN HUMAN DISEASES

VakkasovNozimjon Kabulovich

Международный журнал медицинских наук · 5 · 14-16 · 2025

Аннотация

Oxidative stress represents a critical imbalance between the generation of reactive oxygen species (ROS) and the capacity of antioxidant defenses, leading to cellular and tissue damage. This phenomenon has been implicated in the pathogenesis of various diseases, including cardiovascular disorders, neurodegeneration, cancer, and chronic inflammation. This study provides an overview of the molecular and pathophysiological mechanisms underlying oxidative stress and evaluates its role in disease progression. By reviewing experimental and clinical findings, the article highlights potential therapeutic strategies aimed at modulating oxidativepathways to prevent ormitigate disease outcomes. Keywords:oxidativestress, pathophysiology, free radicals, antioxidant defense, chronicdisease

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«Oxidative stress represents a critical imbalance between the generation of reactive oxygen species (ROS) and the capacity of antioxidant defenses, leading to cellular and tissue damage.»

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Oxidative stress represents a critical imbalance between the generation of reactive oxygen species (ROS) and the capacity of antioxidant defenses, leading to cellular and tissue damage. Полный текст публикации CiteX не хранит — доступ к первоисточнику открывается по DOI согласно лицензии издателя и выбранному плану.

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oxidativestress, pathophysiology, free radicals, antioxidant defense, chronicdisease, oxidative stress, chronic disease
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