MORPHOLOGICAL CRITERIA OF SUBCHONDRAL BONE REMODELING IN POST-TRAUMATIC GONARTHROSIS

Аннотация

Post-traumatic gonarthrosis (PTG) is one of the most significant degenerative-dystrophic diseases of the knee joint. Although the primary damage occurs in the articular cartilage, recent studies have demonstrated that subchondral bone alterations play a decisive role in the early progression of the disease. Morphological remodeling of the subchondral bone is closely interconnected with cartilage degradation and is characterized by osteoblast–osteoclast imbalance, changes in mineralization, and sclerosis. Therefore, the investigation of subchondral bone alterations is of great importance for a deeper understanding of PTG pathogenesis and for the development of effective therapeutic strategies.