HISTOPATHOLOGICAL FEATURES OF LIVER PATHOLOGY IN CHRONIC HEPATOCELLULAR DAMAGE

Аннотация

The liver, as the central metabolic organ, is highly susceptible to toxic, infectious, autoimmune, and metabolic insults. Chronic hepatocellular injury leads to progressive pathological changes that disrupt normal architecture and function. This study aimed to evaluate the histopathological features associated with chronic liver pathology, including steatosis, inflammation, fibrosis, and cirrhosis, and to correlate these changes with their clinical significance. Materials andMethods Liver biopsy specimens from 35 patients with chronic hepatocellular injury (viral hepatitis B and C, alcoholic liver disease, and non-alcoholic fatty liver disease) were analyzed. Routine hematoxylin-eosin (H&E), Masson trichrome, and reticulin staining were performed. Histological grading included assessment of necroinflammation, fat accumulation, and fibrosis stage according to theMETAVIR scoring system.