THE ANTI-HYPERGLYCEMIC EFFECT OF GLIPIZIDE IMPLANTS IN ALLOXAN-INDUCED DIABETIC RABBITS

Аннотация

Glipizide is an oral anti-diabetic medication commonly used to manage hyperglycemia in individuals with type 2 diabetes. In this study, we investigate the anti-hyperglycemic effect of glipizide implants in alloxan-induced diabetic rabbits. Alloxan induction is a well-established model for studying diabetes in animals. Implants containing glipizide were administered subcutaneously to the diabetic rabbits, and their blood glucose levels were monitored over a specified period. The study aims to assess the effectiveness of glipizide implants in reducing blood glucose levels and to evaluate the duration of the anti-hyperglycemic effect. Additionally, the study examines any potential adverse effects or complications associated with the glipizide implants. The findings of this study contribute to the understanding of the therapeutic potential of glipizide implants for the management of hyperglycemia in diabetic rabbits.