A CLINICAL CASE OF ACUTE PROMYELOCYTIC LEUKAEMIA IN A PATIENT WITH RENAL PATHOLOGY

Аннотация

Acute promyelocytic leukaemia (APL) is a distinct subtype of acute myeloid leukaemia characterized by a specific genetic translocation and a high risk of coagulopathy. The coexistence of APL with renal pathology complicates both diagnosis and treatment, requiring a tailored multidisciplinary approach. We report a case of a 47-year-old male with APL complicated by acute kidney injury, presenting with bleeding, pancytopenia, and disseminated intravascular coagulation. Diagnosis was confirmed by bone marrow examination and molecular testing for the PML-RARA fusion gene. Treatment included all- trans retinoic acid and reduced-dose arsenic trioxide, adjusted for renal impairment, along with supportive care addressing coagulopathy, tumour lysis syndrome prophylaxis, and infection management. The patient achieved complete hematologic and molecular remission with restoration of renal function. This case underscores the importance of individualized therapy and vigilant monitoring in managing APL patients with renal complications, demonstrating thatsuccessful outcomes are achievable despitesignificant comorbidities. Key words: Acute promyelocytic leukaemia; Renal pathology; Acute kidney injury; All- trans retinoic acid; Arsenic trioxide; Disseminated intravascular coagulation; Molecular remission;Multidisciplinary management