A Modern View Of Hemostasis Pathology In The Aspect Of Medical Biology

Аннотация

In our work, we analyzed the problems of hemostasis disorders based on literature analysis. Keywords: Aspects, evolution, disorders, organism, enzymes. with various metabolites of protein, lipid, and Introduction: The hemostasis system is an carbohydrate metabolism develop in the body. DIC evolutionarily developed, multi-component protective syndrome is accompanied by a decrease in device of the body. It ensures the processes of anticoagulant potential, depression of fibrinolysis, formation of a fibrin clot and maintaining blood in a which leads to the accumulation of fibrin microclots in liquid state. the bloodstream and the development of multiple Physiological clot formation and lysis is a series of well- organ failure. regulated and balanced interactions between plasma The study of DIC syndrome under the influence of a factors, enzyme cofactors, their regulators, and various thermal agent on the body began in the 1960-1980s. blood cells, as well as the vascular endothelium. The data obtained allowed researchers to conclude The main mechanism of activation of hemostasis that DIC syndrome in severe burns is related to components is limited proteolysis, in which an active disorders in the lungs, kidneys, gastrointestinal tract, enzyme is formed from an inactive precursor, etc.). catalyzing the process of blood clotting or lysis of the However, the main methods for studying the fibrin clot. hemostasis system in those years were such as When compensatory-adaptive hemocoagulation determining blood clotting according to Lee and White, mechanisms fail, the process of blood prothrombin time, thrombin time, plasma microcoagulation is triggered, which accompanies recalcification time, fibrinogen content, and total many pathological conditions, in particular, thermal fibrinolytic activity. burns. The earliest possible diagnosis of DIC syndrome is a Disorders of the hemostasis system occur as critical task, the successful solution of which is the key disseminated intravascular coagulation (DIC to a favorable outcome of the pathological process. syndrome), the development of which leads to Rapid correction of hemostasis normalizes blood progression, a sharp aggravation, and often an supply in parenchymatous organs, restores their unfavorable outcome of the pathological process. function and biosynthesis of biologically active DIC syndrome is always secondary to a general compounds that regulate the coagulation and disturbance of homeostasis. It is characterized by anticoagulation systems. excessive activation of the hemostasis system, leading Changes in hemostasis system parameters can precede to excessive thrombin generation (thrombinemia), the clinical picture of DIC syndrome by 1-1.5 days, accelerated intravascular fibrin synthesis with which allows it to be diagnosed at an early preclinical subsequent blockade of microcirculation in target stage. Laboratory tests, on the basis of which the organs. (lungs, kidneys, liver, gastrointestinal tract, diagnosis of DIC syndrome is made, must meet the brain). In this case, hypoxia, acidosis, and intoxication International Journal of Medical Sciences And Clinical Research 65 https://theusajournals.com/index.php/ijmscr International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265) following criteria: informativeness, efficiency and Such a complex system requires appropriate accessibility for clinical practice, as well as the regulation. This leads to the fact that even small comparative simplicity of the method. disturbances in the delicate balance of pro- and anticoagulant reactions can lead to serious To date, the following tests meet these requirements. consequences for the body: thrombosis and bleeding. 1/. Study of the activity of antithrombin III - the main biological regulator of the hemostasis system, one of Hemophilia - the disease of "royalty" - is an old but still the most powerful natural blood anticoagulants, the relevant disease. main physiological inhibitor of thrombin. It is noted in the literature that hemophilia is one of the Its level in the bloodstream determines the direction of diseases known since ancient times. The first known the pathological process in extreme conditions. descriptions of symptoms similar to the manifestations Determination of AT III activity is a key test for diagnosis of hemophilia were made in Hebrew in the 2nd century and monitoring of therapy of patients with DIC BC. syndrome. 2/. Analysis of the activity of HPA- The authors of literary sources noted the fact that the dependent fibrinolysis. The most "vulnerable" already biblical sages, thanks to the tradition of meticulously at the early stages of the formation of DIC syndrome. tracking genealogies, penetrated into the essence of 3/. Counting the number of platelets, the degree of hemophilia more deeply than doctors and biologists of reduction of which reflects the severity of disseminated the early 20th century. Thus, hemophilia as a intravascular coagulati