HEART FAILURE IN PATIENTS WITH DIABETES MELLITUS

Аннотация

Patients with diabetes mellitus (DM) have more than 2 times the risk of developing heart failure (HF; HF with reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular outcomes, hospitalization, and prognosis are worse in patients with diabetes than in patients without diabetes. In addition to the structural and functional changes characteristic of diabetic cardiomyopathy, they are based on a complex pathophysiological mechanism. Despite the success of many widely used antihyperglycemic drugs in type 2 diabetes, the prevalence of HF remains high. Thus, this raises the possibility that factors other than glycemia may contribute to the increased risk of HF in diabetes. This review summarizes the state of knowledge about the effects of existing antihyperglycemic drugs on HF and discusses potential mechanisms for beneficial or negative effects.