STATE OF THE CYTOKINE PROFILE IN FREQUENTLY ILL CHILDREN WITH ACUTE OBSTRUCTIVE BRONCHITIS

Аннотация

Оbstructive bronchitis remains one of the most common and severe diseases of the respiratory system in children [8]. Understanding the pathogenetic role of the immune status, cytokines can contribute to a deeper understanding of the mechanisms of disease development in obstructive bronchitis, to develop effective strategies for diagnosing and treating the disease in frequently ill children. The purpose of the scientific study is to study the state of cytokines in frequently ill children with acute obstructive bronchitis. Material and methods of research: in order to establish the relationship with the indicators of the cytokine profile, a survey was conducted of 120 patients with acute obstructive bronchitis divided into 2 groups: group I - 40 patients with acute obstructive bronchitis from the group "episodic ill children", group II - 80 patients with acute obstructive bronchitis from the group of "frequently ill children". The study showed that cytokines are one of the key mediators of pathogenesis, regulate the recruitment and activation of immune cells and inflammatory processes in the respiratory tract. Understanding the role of cytokines in obstructive bronchitis in children can give an idea of the mechanisms, features of the course, potential diagnostic and therapeutic measures of the disease.