THE ROLE OF CYTOKINE PROFILE IN THE DEVELOPMENT OF CORONARY HEART DISEASE IN COMORBIDITY WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Аннотация

Purpose of the study: to determine the relationship between the levels of cytokines (IL-1β, IL-6; IL-10, TNF-α) and the clinical course of coronary artery disease in COPD. Material and methods: this study is based on the results of observation of patients with coronary artery disease hospitalized in the period from 2021-2022. in the departments of somatic resuscitation, emergency therapy No. 1, 2 of the Samarkand Branch of the Republican Scientific Center for Emergency Medical Care (SF RSCEMC). The study involved 88 patients with coronary artery disease and COPD, which were divided into 2 groups depending on gender. As a result of the study, the relationship between the concentration of pro-inflammatory interleukins and severe courses of coronary artery disease with COPD was revealed, which allows us to recommend its use as an additional laboratory indicator for these pathologies, and allows us to identify groups with a low and high risk of developing various complications. At the same time, in patients with high expression of TNF-α, IL-6 and IL-1β in the blood, a complicated course of the disease is predicted. Early identification of categories of patients with coronary artery disease and COPD with an increased risk of complications will allow the use of more active methods of treatment (medication and/or surgery) for such patients.