CORRECTION OF VITAMIN D LEVELS IS THE KEY TO PREVENTING HYPOCALCEMIC CONDITIONS

Аннотация

Objective: Determination of the level of 25(OH)D3 in blood serum and its effect on the prevention of rickets in Uzbekistan. Methods: There were 466 children under observation, aged from 1 to 12 months, the children were considered practically healthy and did not receive vitamin D within a month before blood sampling. The level of vitamin 25(OH)D3 less than 30 mmol/l was considered an existing biochemical deficiency. Results: Despite the traditional prevention of rickets, 27.8% had mild and moderate severity, while 72.1% had no clinical signs of rickets. In 86.1% of children with rickets, a low level of 25(OH)D3 in the blood serum was detected. Thus, after the modified prevention of rickets, only in 9.2% of the examined children with signs of rickets, did the level of 25(OH)D3 remain low, while in 90.7% it returned to normal. At the same time, in children without signs of rickets, 14.3% had a low content of 25(OH)D3 in the blood serum, and in 85.7% of children, the level returned to normal. As a result, the correct administration of vitamin D makes it possible to reduce severe forms of rickets and improve the psychomotor development of the child. Conclusions: The proposed correction with vitamin D allows us to normalize the level of 25(OH)D3, reduce severe forms of rickets, improve psychomotor development in the 1st year of life and can be recommended in the conditions of Uzbekistan.