LABORATORY DIAGNOSTICS OF INFLAMMATORY METAMORPHISM AND MARKERS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC PAIN SYNDROME WITH BRUCELLOSIS GENESIS DORSOPATHY

Аннотация

Purpose: to analyze the results of laboratory diagnosis of inflammatory metamorphism and markers of endothelial dysfunction in patients with chronic pain syndrome in dorsopathy of brucellosis origin. Material and methods: Cluster analysis was applied to process a standardized set of clinical and laboratory parameters studied in 106 patients in the period from 2020 to 2022, who are being examined and treated in the Samarkand City Infectious Diseases Hospital with a diagnosis of chronic brucellosis. Results. Based on the results of multivariate analysis, parameters were identified that are a pathogenetic factor of inflammation, leading to pain and stimulating the production of pro-inflammatory cytokines. Conclusions.1. The high value of the study of inflammatory markers of endothelial dysfunction in patients with chronic brucellosis is shown. 2. Correlation analysis of inflammatory markers of endothelial dysfunction revealed that they could be considered as a pathogenetic factor of inflammation leading to pain