PECULIARITIES OF CYTOCHEMICAL PARAMETERS OF PERIPHERAL BLOOD LYMPHOCYTES IN CHILDREN WITH HEREDITARY HEMOLYTIC ANEMIA

Аннотация

Activity of redox enzymes of Krebs cycle in 60 children at the age from 2 to 15 years old with hereditary hemolytic anemia (HHA) was studied. Functional activity of peripheral blood lymphocytes was investigated by cytochemical method proposed by Narcissov R.P. in 1969. The study of the cytochemical status of peripheral blood lymphocytes of all three groups of patients revealed inhibition of the activity of energy metabolism enzymes - succinate dehydrogenase (up to 11.54±0.25) and alpha-glycerophosphate dehydrogenase (up to 5.37±0.21). Changes in the structure of lymphocyte population were also found. The carried out investigation showed inhibition of redox enzymes activity (SDH and alpha - GPDG) in children with HHA, which indicates marked metabolic disorders, and, accordingly, indicate reduced compensatory possibilities of the children's organism at the cellular level.