CLINICAL AND MORPHOLOGICAL SUBSTANTIATION OF CORRECTION OF THE COURSE OF CHEMOTHERAPY IN THE SURGICAL TREATMENT OF LIVER ECHINOCOCCOSIS

Аннотация

Experimental studies on sheep have shown that stimulation of a proliferative-productive cellular reaction around the germinal cyst of a parasite with an inhibitory effect when using albendazole at a dose of 10-15 and 20 mg/kg occurs within 2 weeks, while at a dose of 5-7 mg/kg the effect came to 3-4 weeks of observation. Studies allow us to adjust the recommended dose of albendazole from 10-12 mg/kg in cases of a possible risk of developing toxic reactions (diffuse liver disease) to 5-7 mg/kg, taking into account the prolongation of the course of treatment. Clinically justified is the use of an adjusted dose of albendazole 5-7 mg/kg for the prevention of recurrence of liver echinococcosis in patients with concomitant chronic diffuse liver pathology, which made it possible to reduce the likelihood of adverse reactions and the frequency of recurrence of the disease from 11.9% to 2.6%.