INFLUENCE OF TRIMETAZIDINE ON MYOCARDIAL CAPILLAROMETRIC PARAMETERS DURING DOXORUBICIN-CYCLOPHOSPHAMIDE MODE OF CHEMOTHERAPY ADMINISTRATION

Аннотация

AC-mode of chemotherapy is the gold standard of breast cancer treatment. The components of the above-mentioned mode of chemotherapy are doxorubicin and cyclophosphamide. Both drugs, in addition to a pronounced cytotoxic and cytostatic effect, also have a significant cardiotoxic potential, which is manifested by widely variable cardiac symptoms. In the present study, the impact of the AC chemotherapy regimen on the myocardial microvasculature was studied, with the simultaneous assessment of the capillary-protective properties of trimetazidine.