PROGNOSTIC CLINICAL MARKERS OF RENAL FAILURE IN METABOLIC SYNDROME

Аннотация

The high prevalence of obesity is a serious medical and social problem. Recent studies have shown that the risks of developing the metabolic syndrome are associated not so much with the volume of fat mass as with its hormonal and metabolic activity, which served as the basis for the formation of the concept of metabolic health, which formed the basis of the modern classification of obesity. However, the definitions of its phenotypes remain debatable. Obesity is also one of the significant risk factors for the development of chronic kidney disease (CKD), while there is no consensus on the contribution of different obesity phenotypes to the development of renal disorders. Pilot studies have proven the possibility of using markers of early kidney damage to detect renal dysfunction in patients with metabolic syndrome. There are few data on the relationship between markers of preclinical kidney damage and parameters characterizing the hormonal and metabolic component of obesity. Epidemiological studies have shown a high prevalence of CKD combination in obese patients. Studies aimed at determining the contribution of various obesity phenotypes to the formation of renal disorders were carried out mainly in the Asian population. There is no information on the role of a metabolically healthy obesity phenotype in the development of preclinical renal dysfunction. Determining the genetic predisposition to the development of obesity is a promising area of ​​modern medicine.