AUTOANTIBODIES, IMMUNOREACTIVITY PROFILES AND THEIR CONNECTION WITH DISEASES

Аннотация

The synthesis of natural auto-ABs in a healthy organism is maintained within certain limits necessary for the latter to perform certain regulatory functions, and their excess, as well as insufficient production, can lead to the development of pathological conditions. The study of autoantibodies that reflect the imunculus - a molecular cast of the body at the current time point, allows us to draw conclusions at an intermediate level between transcriptomics and metabolomics, i.e. still at the preclinical stage, being a kind of "biochemical biopsy" The data presented in the literature indirectly indicate that a deep analysis of changes in the serum content of autoantibodies today is the most effective tool for preclinical diagnosis of most diseases, which must be introduced into medical practice