COMPARATIVE ANALYSIS OF WOLFRAM AND ALSTROM SYNDROMES

Аннотация

Wolfram syndrome and Alström syndrome are rare monogenic autosomal recessive multisystem disorders that manifest in childhood or adolescence. Despite certain overlapping clinical features (such as early-onset diabetes mellitus, progressive visual and hearing impairment), these syndromes differ in their genetic causes, pathogenesis, clinical course, and prognosis. This article provides a comparative analysis of the two syndromes.