CLINICAL AND CARDIOGRAPHIC CHANGES IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKAEMIA AND METHODS FOR THEIR CORRECTION

Аннотация

Objective: To analyze the clinical and electrocardiographic changes in patients with acute lymphoblastic leukemia (ALL) and evaluate the methods of their correction. Materials and Methods: The study included 40 patients aged 18 to 40 years with newly diagnosed ALL who underwent polychemotherapy. ECG and EchoCG were performed before and after treatment. Additional tests included complete blood count, urinalysis, lipid profile, coagulation time, and coagulation profile. Results: Electrocardiographic abnormalities were found in 90% of patients, including sinus tachycardia, extrasystoles, atrial fibrillation, ST segment changes, and QTc prolongation. EchoCG showed reduced left ventricular ejection fraction in 75% of patients. Cardioprotective therapy and regular monitoring improved outcomes. Conclusion: Cardiographic monitoring is essential in ALL treatment to prevent and correct cardiotoxicity. Cardioprotective agents such as ACE inhibitors and dexrazoxane are recommended.