MORPHOLOGICAL CRITERIA OF AGGRESSIVENESS IN PHYLLODES TUMORS OF THE BREAST IN THE CONTEXT OF PREDICTING CLINICAL OUTCOMES

Аннотация

This review article analyzes the morphological and immunohistochemical criteria of aggressiveness in phyllodes tumors of the breast. Key prognostic parameters-including cellular atypia, mitotic activity, stromal hypercellularity, Ki-67, and p53 expression-are examined in relation to clinical outcomes. Differences in interpretation among authors are highlighted, emphasizing the need for standardized diagnostic criteria and prognostic assessment strategies.