DYNAMICS OF BIOCHEMICAL INDICATORS OF PATIENTS WITH COMPLICATED FORMS OF CHRONIC PURULENT OTITIS MEDIA DURING TREATMENT

Аннотация

Clinical studies involved 148 patients with chronic suppurative otitis media (CSOM) with complications. The high frequency of complications in CSOM, including fatal cases, necessitates a detailed analysis of the patterns of their occurrence, as well as the development of an effective treatment and diagnostic strategy. As a result of the infectious process, as part of the body's protective reaction, an increase in endogenous intoxication indicators is observed, an increase in body temperature above 38 ° C, the development of tachycardia and tachypnea, a shift in the leukocyte formula to the left, as well as an increase in the erythrocyte sedimentation rate (ESR) and the level of C-reactive protein. Also, inflammatory processes in the body are caused by damage to cellular and subcellular structures that occur under the influence of lipid peroxidation products (LPO) and metabolites of endogenous intoxication. During the pathological process, the rheological properties of the blood change, which contributes to the disruption of cerebral circulation in the vertebrobasilar system. Hypoxemia and metabolic acidosis play a key role in the pathogenesis of lesions of the cellular structures of the middle and inner ear. With chronic suppurative otitis media with complications, auditory perception is affected to some extent in almost all cases. This article discusses modern methods of complex diagnostics and principles of treatment of chronic purulent otitis media with complications. The combined use of hyperbaric oxygenation with antioxidants and plasmapheresis helps to improve biochemical blood parameters and audiological characteristics. The data obtained confirm the effectiveness of the proposed diagnostic and therapeutic approaches, which can form the basis for further improvement of treatment strategies.