THE IMPORTANCE OF ENDOGENOUS INTOXICATION INDICATORS IN THE DIAGNOSIS AND TREATMENT OF ALLERGIC RHINITIS

Аннотация

The condition of endogen intoxication during the treatment with topical steroids for allergic rhinitis has been studied insufficiently. Suprastineks (levoсetirizini digidroxloridi) was used during the study which is able to inhibit release of mediators of allergic reactions, blocks H1-histamine receptors. The drug affects the histamine-dependent stage of allergic reactions, reduces eosinophil migration, reduces vascular permeability, and limits the release of inflammation mediators. Under the influence of levoсetirizini content of MDA decreased to 42.6%, the activity of catalyses plasma increased to 60.0%, a decline of ratio MDA/CA 80.4%, decreased concentration MSM254 and MSM280 45, 0 and 35.5%, respectively, significantly moved them closer to the healthy group.