SAFETY EVALUATION OF A BIOLOGICALLY ACTIVE SUPPLEMENT FORMULATED FROM MOMORDICA CHARANTIA CULTIVATED IN BUKHARA

Аннотация

This study focuses on evaluating the acute toxicity of a biologically active food supplement developed from Momordica charantia (bitter melon) cultivated in the Bukhara region of Uzbekistan. Known for its antioxidant, antidiabetic, and immune-enhancing properties, this plant holds significant potential in the development of functional food products. During the experiment, white rats were administered single doses of the supplement ranging from 2000 to 5000 mg/kg via oral gavage. Over a 21-day observation period, no signs of toxicity or mortality were recorded. The LD₅₀ was determined to exceed 5000 mg/kg, indicating the non-toxic nature of the product. These findings confirm the toxicological safety of the supplement and support its potential application as a nutraceutical.