MODERN EPIDEMIOLOGICAL RISK FACTORS FOR THE REALIZATION OF LATENT TUBERCULOSIS INTO LOCAL FORMS IN CHILDREN

Аннотация

Purpose of the research. Conduct an analysis of modern epidemiological risk factors for the realization of latent tuberculosis infection into local forms of tuberculosis in children living in tuberculosis infection foci, with the aim of further optimizing the detection in the conditions of the general treatment network, as well as observation in the conditions of the tuberculosis dispensary. Materials and methods. 62 children with LTD living in tuberculosis infection centers were selected. These children were re-examined 12 and 24 months after the completion of preventive chemotherapy for LTD. The children were divided into two groups. The 1st group included 33 children with latent tuberculosis infection, which progressed into active tuberculosis; The 2nd group consisted of 27 children who did not progress from LTD to active tuberculosis. Results. The modifying role of factors such as living in a Covid-19 hotspot: mother is sick (RR 3.250), father is sick (RR 8,000), HIV infection hotspot: father is sick (RR 8,000) has been established. The significance of such a factor as the territorial focus of tuberculosis infection was established: school (RR 4,500), "former" tuberculosis focus (RR 8,000). Conclusions. Today, living in a Covid-19 hotspot, an HIV infection hotspot, and a regional tuberculosis hotspot (school, "former" tuberculosis hotspot) should be considered as a modern epidemiological risk factor for the implementation of LTD into local forms of tuberculosis among children, from tuberculosis infection foci.