ASSOCIATION OF P2RY12 GENE POLYMORPHISM WITH ARTERIAL HYPERTENSION AMONG MILITARY PERSONNEL

Аннотация

The results of the study showed that the heterozygous H1/H2 genotype was most common among servicepersons with AH, indicating its association with an increased risk of the disease. In the control group, the homozygous H1/H1 genotype prevailed, indicating its lower frequency among individuals with AH. Correlation analysis confirmed the association between the heterozygous genotype and a more severe degree of hypertension, which allows us to consider it an important factor for assessing the severity of the disease. H2 allele genotypes showed no significant association with the development or severity of AH. Thus, the importance of P2RY12 gene polymorphism as a possible marker of predisposition to arterial hypertension is confirmed. Thus, the results may serve as a basis for the development of new methods of early diagnosis and prevention of AH, as well as for the creation of personalized programmes of treatment and control of the disease, which will significantly increase the effectiveness of preventive measures among military personnel and other population groups.