COMPARISON OF ALLELE AND GENOTYPE FREQUENCIES OF THE UMOD GENE POLYMORPHISM RS4293393 BETWEEN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS AND A CONTROL GROUP

Аннотация

This study focuses on the comparative analysis of allele and genotype frequencies of the UMOD gene polymorphic marker rs4293393 in patients with chronic glomerulonephritis (CGN) and a control group. The aim is to identify potential associations between allelic variants and the risk of CGN. Data collection and analysis revealed the distribution of alleles C and T among patients and controls. Allele C was found more frequently in patients with CGN than in the control group (30.91% vs. 25.84%, OR = 1.28, 95% CI: 0.80–2.05), though statistical significance was not achieved (p = 0.356). Conversely, allele T was less frequent among patients (69.09% vs. 74.16%, OR = 0.78, 95% CI: 0.49–1.24), also without statistical significance (p = 0.356). The results suggest a weak association between the UMOD rs4293393 polymorphism and CGN risk, warranting further research for confirmation.