PATHOGENETIC MECHANISMS OF "EPITHELIAL-MESENCHYMAL TRANSITIONS" IN THE DEVELOPMENT OF ADHESIVE DISEASE DURING SURGICAL INTERVENTIONS IN GYNECOLOGY

Аннотация

The article presents data on the participation of "epithelial-mesenchymal transitions" in the pathogenetic mechanism of adhesion process development in women who have undergone gynecological surgeries. The pathogenetic mechanism of participation of matrix metalloproteinases-2 and 9 and tumor necrosis factor-a in the development of adhesions in women who have undergone gynecological surgeries has been proven. Their high levels indicate a destructive effect on the extracellular matrix, creating conditions for the development of adhesions due to the growth of fibrous tissue. The range of MMP-2 levels >400 pg/ml, MMP-9 >350 pg/ml and TNF-α >45 pg/ml in determining the risk of adhesions after gynecological surgeries has been established.