Distribution Of PPARG Gene Pro12Ala Polymorphism

Аннотация

The present study reports for the first time the genotypic distribution of PPARG Pro12Ala polymorphism in group of Uzbek athletes. The human peroxisome proliferator-activated receptor gamma (PPARγ) is involved in lipid storage, glucose homeostasis and adipocyte differentiation. Pro-allele contributes to the development of high physical performance in sports where you need extra physical stamina, and Ala-allele - in sports based on the strength and speed. An analysis of the distribution frequency of genotypes of the PPARG gene, based on the general model of inheritance, in the group of athletes involved in football, was statistically significant compare to control (p =0.004). These results suggest that the presence of PPARG Ala allele, which increases the sensitivity of muscle tissue to insulin, and thus enhancing its anabolic effect on skeletal muscle, predisposes the development and display of speed-power qualities. In addition, we are studied frequencies of Pro/Ala genotypes in Uzbek population in comparison with Russian, Ukrainian, Italian, Bosnian and Herzegovinian, and Ethiopian samples. In conclusion, the present data seem to suggest that some selective factors such as climate could have influenced the present distribution of the Ala allele.