USE OF NITRIC OXIDE THERAPY IN NEUROLOGICAL AND NOSOGENIC PSYCHOPATHOLOGICAL CONDITIONS DEVELOPING IN CANCER DISEASES OF THE REPRODUCTIVE SYSTEM

Аннотация

В данной статье анализируются неврологические расстройства и нозогенные психопатологические состояния (депрессия, тревожные состояния, когнитивное снижение), встречающиеся у пациенток с раком репродуктивной системы (эндометриальный, рак яичников, рак предстательной железы и т.д.). Рассматриваются исследования, посвященные эффективности применения оксида азота (NO) - эндогенного вазодилататора и нейромодулятора в таких случаях. Также анализируются научные подходы к патофизиологическим основам и клиническому применению терапии оксидом азота. Ключевые слова: оксид азота, рак, репродуктивная система, неврология, психопатология, терапия, нозогенная реакция. https://scientific-jl.com/wsrj 3 6 2 Volume-39_Issue-1_May-2025 World scientific research journal РЕПРОДУКТИВ ТИЗИМ САРАТОН КАСАЛЛИКЛАРИДА РИВОЖЛАНУВЧИ НЕВРОЛОГИК ВА НОЗОГЕН ПСИХОПАТОЛОГИК ҲОЛАТЛАРДА NITRIC OXIDE (АЗОТ ОКСИДИ) ТЕРАПИЯСИНИНГ ҚЎЛЛАНИЛИШИ Ёдгоров Жасурбек Жўраевич Абу Али ибн Сино номидаги Бухоро давлат тиббиёт институти. Бухоро, Ўзбекистон. e-mail: yodgorov.jasurbek@bsmi.uz Аннотация Ушбу мақолада репродуктив тизим саратон касалликлари (эндо-метриал, тухумдон, простата бези саратонлари ва ҳоказо) билан оғриган беморларда учрайдиган неврологик бузилишлар ва нозоген психопатологик ҳолатлар (депрессия, анксиоз ҳолатлар, когнитив пасайиш) таҳлил қилинади. Азот оксиди (NO) — эндоген вазодилататор ва нейромодулятор сифатида бундай ҳолатларда қўлланилишининг самарадорлигига бағишланган тадқиқотлар кўриб чиқилади. Шунингдек, азот оксиди терапиясининг патофизиологик асослари ва клиник қўлланилиши бўйича илмий ёндашувлар таҳлил қилинади. Калит сўзлар: азот оксиди, саратон, репродуктив тизим, неврология, психопатология, терапия, нозоген реакция. Reproductive system cancers are a major threat to women's and men's health on a global scale. These diseases cause not only physical, but also mental and neurological complications. In the post-diagnosis period and, in particular, during oncological therapy, many patients experience depression, anxiety, cognitive impairment, and somatoform disorders. Several pathogenic mechanisms are involved in the occurrence of these conditions, including inflammation, hypoxia, hormonal changes, and disorders of the neurotransmitter system. From this point of view, nitric oxide (NO) - as a neuromodulator and a signaling molecule - opens up new possibilities in the treatment of such complex conditions. Nitrogen oxide (NO) is a gaseous signaling molecule that is endogenously produced in the body and plays an important role in various physiological and pathophysiological processes. Its main functions include ensuring vasodilation, modulating neuronal activity, controlling inflammatory processes, and implementing neuroprotective and antidepressant effects. The role of NO in vasodilation is to improve blood flow and lower blood pressure by relaxing the muscle fibers of blood vessels. At the same time, NO acts as a neurotransmitter in the central nervous system, modulating the transmission of signals by neurons, which is important in the balance of cognitive functions and emotional states. From a pathophysiological point of view, NO is also involved in inflammatory reactions. Imbalance of its quantity and activity can lead to chronic forms of https://scientific-jl.com/wsrj 3 6 3 Volume-39_Issue-1_May-2025 World scientific research journal inflammation and the development of various diseases, including cancer, neurodegenerative and cardiovascular diseases. Also, scientific research has confirmed that NO plays an important role in neuroprotective processes, protects nerve cells from various damages, and has an antidepressant effect. Thus, the role of nitric oxide in physiological and pathophysiological processes is broad and complex, and understanding its functions is important for the development of new therapeutic approaches in the treatment of cancer and neurological complications. Studies conducted in recent years have shown that oncological diseases, in particular, cancers of the reproductive organs, can cause various neurological and psychopathological complications. In the process of these diseases, the following conditions are common: Depressive and anxious states, which develop after diagnosis as a result of psychological shock, hormonal changes, and chemotherapy; Chronic fatigue syndrome (fatigue), i.e., a state of continuous fatigue and weakness; Decreased cognitive functions, so-called "chemo brain," memory problems, and difficulty concentrating; Autonomic nervous system dysfunction, which leads to various physiological disorders. These types of neurological and psychopathological complications significantly reduce the quality of life of patients and complicate their adaptation to the treatment process. Therefore, comprehensive psychological and neurological support for patients with reproductive cancers is necessary. NO therapy in the form of inhalation. This method is mainly used in cases associated with adhesions or hypox