GENETIC MONITORING AND CONTROL OF DRUG-RESISTANT M. TUBERCULOSIS STRAINS IN THE REGION

Аннотация

This study focuses on the genetic monitoring of drug-resistant Mycobacterium tuberculosis (MDR/XDR-TB) strains in a high-burden region of Central Asia. A total of 360 clinical isolates were collected and analyzed using whole-genome sequencing (WGS) to detect resistance-associated mutations and determine the genetic structure of circulating strains. The most common mutations were found in katG, rpoB, gyrA, and Rv0678. The study revealed high regional prevalence of the Beijing lineage (58%). Genomic data enabled identification of transmission clusters and geographic resistance patterns. These findings provide a foundation for molecular surveillance and targeted interventions in tuberculosis control programs across the region.