СОСТОЯНИЕ ГУМОРАЛЬНОГО ИММУННОГО ОТВЕТА К ГЕРПЕСВИРУСАМ У ПАЦИЕНТОВ С ХРОНИЧЕСКИМ РЕЦИДИВИРУЮЩИМ АФТОЗНЫМ СТОМАТИТОМ РАЗЛИЧНОЙ СТЕПЕНИ ТЯЖЕСТИ

Аннотация

To assess the effect of herpesvirus infection on the development and severity of the clinical course of recunent aphthous stomatitis of the oral cavity. Material and methods: The study included patients with chronic recurrent aphthous stomatitis aged 18 to 60 years, including 63 men and 80 women. The control group consisted of 46 apparently healthy individuals without chronic diseases and acutepathology at the time of examination.Results: A high clinical significance of the detection of “persistent” and “reactivated” variants of the course of herpesvirus infection in the development of chronic recunent aphthous stomatitis was established: “persistent” course was observed in 48.95% of the examined (13.04% in the comparison group), “reactivated” - respectively 23.08 and 8.69%.Conclusions: The severity of the clinical course of chronic recurrent aphthous stomatitis is associated with an increase in the frequency of detection of specific antibodies of the IgG and IgM classes in herpesvinis infection.