ХАРАКТЕРИСТИКА ИММУНОГО СТАТУСА У ВИЧ-ИНФИЦИРОВАННЫХ ДЕТЕЙ С ОСТРЫМ РИНОСИНУСИТОМ

Аннотация

The immune status has been studied at 35 HIV-infected of children with ARS. The control group of comparison consisted from 14 practically healthy faces. At a HIV-infected of patients with ARS has revealed deep infringements of the immune status, especially from the T-link of immunity and its subpopulations, and also frustration humoral an immunity link, suppression of proinflammatory cytokine IL-10 and increase proinflammatory IFN-γ. Under the influence of the spent treatment have not revealed OPEN ACCESS certain changes from the immune status at patients. It is possible to ascertain only positive IJSP changes of maintenance IL-10 and parallel decrease IFN-γ in dynamics of treatment. In the main group there were 25 HIV-infected patients with ARS, and in the control group there were 14 practically healthy children of the same age who did not have a history of ARS and HIV. All 35 HIV-infected children were registered with the Bukhara Regional AIDS Center. Patients received antiretroviral therapy, antibacterial, anti-inflammatory and local therapy in a hospital setting. Key words: the immune status, a HIV-infection, acute rhinosinusitis, cellular immunity, humoral immunity, an immunodeficiency, cytokines. The problem of infection caused by the human immunodeficiency virus (HIV) has been studied in otorhinolaryngology in our country since the early 1990s. Identified and described diseases that are an indicator of acquired immunodeficiency syndrome (AIDS), studied the symptoms Academic Editor: Arzikulov A. of lesions of the ear, throat and nose in HIV-infected and AIDS patients Professor, Andijan State Medical Institute (1,3,5). Due to a significant increase in the number of cases of HIV infection, the Received: 10 July 2022 Accepted: 22 July 2022 likelihood of contact of an otorhinolaryngologist with HIV-infected patients is Published: 30 July 2022 increasing. With HIV infection, various manifestations of the disease often Publisher’s Note: IJSP stays occur with damage to the upper respiratory tract. Otorhinolaryngologists, neutral with regard to jurisdictional as well as other specialists, already have to take an active part in the claims in published maps and institutional affiliations. diagnosis, treatment of HIV-infected persons, preventive work, which, of course, will require knowledge of the features of the pathology of the ear, throat and nose in HIV infection (AIDS) (2, 8.9). The variety of clinical manifestations of HIV infection is due to the Copyright: © 2022 by the authors. Licensee IJSP, Andijan, addition of opportunistic infections, among which fungal, bacterial and viral Uzbekistan. This article is an open infections are of the greatest importance. The classic manifestation of HIV access article distributed under infection that an otorhinolaryngologist may encounter is the development the terms and conditions of the Creative Commons Attribution of acute rhinosinusitis. Acute rhinosinusitis is one of the most common (CC BY-NC-ND) license (https:// bacterial infections in children with a normal immune system, but the creativecommons.org/licenses/by- nc-nd/4.0/). features of the course of these diseases in immunodeficiencies are poorly understood.Meanwhile, our own experience and the few data from clinical studies that are available today suggest that this disease, in acute, chronic and recurrent forms, is common in HIV-infected children.And although in most cases the etiology, symptoms and course of these diseases in HIV-infected children and in children with a normal immune system are the same, nevertheless, a prolonged, severe or unusual course of these infections, with frequent relapses, or the isolation of atypical pathogens (including pathogens of opportunistic infections) should alert the physician to possible HIV infection. This disease has long attracted the attention of otorhinolaryngologists and paediatricians, especially since observations and studies have appeared indicating an association of acute rhinosinusitis with HIV infection (6,7,10). www.ijsp.uz 40 2022 / Issue 03 / Article 04 International Journal of Scientific Pediatrics published: 30 July 2022 The aim of the study was to study the parameters of the immune system in HIV-infected children with acute rhinosinusitis. Material and Methods We investigated 35 children at the age from to 3 till 14 years of a HIV-infected with ARS, were on hospitalization in LOR-BRANCH of the Bukhara regional children’s versatile medical centre. Boys have made 56.6%, girls – 43.4%. Unilateral defeat of sine was observed at 57.8%, bilateral - at 42.2%. Except inflammation signs the general anxiety, a bad dream, refusal of a chest food, headaches was marked. Besides traditional inspection (the general analysis of blood, urine, bacteriological and bio-chemical researches) all patients have passed LOR-survey, under indications - sine sounding (26.5%), X-ray additional bosoms of a nose (9.6%). In the basic group there were 25 HIV-infected with ARS pa-tient