CLINICAL-LABORATORY CHANGES IN THE DEVELOPMENT OF LIVER CIRRHOSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND CHRONIC VIRAL HEPATITIS B

Аннотация

Liver cirrhosis remains a significant long-term complication of chronic viral hepatitis, particularly in patients infected with hepatitis C virus (HCV) and hepatitis B virus (HBV). This study investigates the clinical and laboratory changes associated with the progression from chronicviral hepatitistoliver cirrhosis. Across-sectional analysis was performed on250patients diagnosed with chronic hepatitis (150 with HCV and 100 with HBV) along with a control group of 80 healthy subjects [1]. Clinical parameters—including liver function tests, coagulation profiles, and ultrasound findings—were evaluated alongside immunological markers such as cytokine levels and viral load quantification. The results demonstrate significant alterations in biochemical and immunological parameters as cirrhosis develops, with notable differences between hepatitis C and B infections. These findings may improve early diagnostic accuracy and help guide therapeuticstrategies todelay cirrhosis progression [2]. Keywords: chronic viral hepatitis, liver cirrhosis, hepatitis C, hepatitis B, clinical-laboratory changes, immunological markers