Selection of the optimal composition and technology of the recommended capsules "PROSTAD"

Аннотация

In the process of searching for new effective drugs for the treatment of prostate and prostate adenoma, special attention should be paid to drugs based on natural origin. It is generally accepted that drugs obtained from natural origin are less toxic. The action of these drugs is carried out through ready-made dosage forms that are easy to use. The purpose of our work is to develop the composition and technology of an encapsulated dosage form based on Fireweed.This article presents the results of studies on the development of tablet technology based on the recommended dry extract "Prostad". An encapsulated dosage form, unlike others, does not require the mandatory introduction of excipients if the drugs have satisfactory technological properties. They can be filled into gelatin capsules, which significantly simplifies the technological process of production. Having a complete description of the properties of the compressed substance, it is possible to scientifically approach the solution of this problem. Keywords: Hygroscopicity, humidity, substance, dry extract, compressibility, fractional composition, bulk density, flowability, physicochemical. "Prostad" is a finely dispersed homogeneous powder Introduction: Selection of the optimal composition and with particle sizes from 2.9 μm to 4.8 μm. The increased technology of the recommended capsules "Prostad". force of attraction between the particles of the extract, The main important technological properties of due to the particle size (2.75-4.62 μm), is the reason for powders - substances in relation to solid dosage forms poor flowability and relatively low bulk density. Along include the following indicators: appearance, fractional with the above, it should be noted that the fractional composition, solubility, flowability, bulk density, angle composition of the extract is the following indicators: - of repose, porosity, compactibility, hygroscopicity, 3000 + 2500 μm ~ 14.91%, -2500 + 1000 μm - 29.65% - residual moisture [1]. 1000 + 315 μm - 40.18%, - 315 + 250 μm - 10.99%, -250 Based on the above (Chapter II), in preliminary studies μm - 4.34%. we studied the obtained dry extracts according to our The above results of the study indicate that the dry recommended technology and conditions. The extract "Prostad" is an amorphous, finely dispersed obtained extract is dry hygroscopic, finely dispersed powder and in a free state is prone to the formation of powders from red to dark brown color with a specific conglomerates. Such powders in relation to their solid odor. When shaken with water, it forms a colloidal dosage forms are difficult and to achieve the necessary solution. It has a unique smell and taste. Microscopic technological properties of the mass it is necessary to examination of the powders was carried out using a use the appropriate compositions of auxiliary Neophot-21 microscope manufactured by Carl Zeiss at substances, as well as to carry out special technological a magnification of 170 times, followed by photography. methods. The study of the physicochemical properties The results of the study showed that the dry extract International Journal of Medical Sciences And Clinical Research 21 https://theusajournals.com/index.php/ijmscr International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265) of the dry extract of Fireweed showed that the extracts dosage forms, it will be necessary to use a set of are dry hygroscopic, finely dispersed powders of dark auxiliary substances and technological operations. brown color with a specific odor, the loss in mass during Since when studying the technological indicators drying was 3.56%, heavy metals 0.0092, when (fractional composition, bulk density, flowability, angle determining the moisture content of the dry extract of of natural repose, compressibility coefficient, the extract is equal to 4.77%, the quantitative content compactibility coefficient, porosity, residual of biologically active substances is 91.78%.[2-6]. moisture...) unsatisfactory values of almost all technological properties were predicted. The recommended dry extract is characterized by hygroscopicity, insufficient flowability, the angle of RESULTS AND DISCUSSIONS natural slope it is not possible to obtain granules (for Selection of the optimal composition and technology of the preparation of, for example, encapsulated dosage the recommended capsules "Prostad". The study of the forms) without introducing auxiliary substances into physicochemical and technological properties of the the composition that improve the technological substance have a predictive value in the selection of the characteristics of the mass. optimal composition and technology of dosage forms Experimental section [2]. METHODS Further study of the technological properties of the dry extract showed that when developing the technology This study develops encapsulated dosage forms from of solid dosage forms, it is necessary to use a set of Epilobium angustifo