Prospects for The Development of Enterosorbent Preparations Based on Local Glauconite Mineral Raw Materials

Аннотация

Enterosorbents are widely used in gastroenterology, toxicology, infectious diseases, allergology, dermatology, surgery, oncology, hepatology, nephrology, and addiction medicine. To expand the range of enterosorbent preparations using natural raw materials, the physicochemical and technological properties of the natural mineral glauconite were studied as a promising source for the developing granulated, encapsulated, and tablet-form oral enterosorbent preparations. Keywords: Enterosorbent, adsorption, absorption, endotoxins, exotoxins, technology, oral preparations, granules, and capsules. Introduction: The development of enterosorbent In the cases mentioned above, the mechanism of preparations with adsorption and detoxification sorption is related to both direct and indirect effects. pharmacological effects is one of the promising areas in The therapeutic-chemical classification of pharmaceutical practice. enterosorbents includes compounds such as activated charcoal, bismuth preparations, pectin, kaolin, Enterosorbents are medicinal substances of various croscarmellose, attapulgite, diosmectite, and their structures and nature, whose mechanism of action is combined compositions [1, 2]. aimed at binding and eliminating exo- and endotoxins from the body through the gastrointestinal tract by Currently, enterosorbent preparations are mainly adsorption, absorption, ion exchange, and complex imported into Uzbekistan from abroad and do not fully formation. Depending on the mechanism of action, meet the needs of our country. Therefore, expanding sorbents can be divided into: 1) adsorbents - the range of preparations with sorptive properties is an substances with ion-exchange properties; 2) urgent task for modern pharmaceutical technology. complexing agents - substances that, in a molecular or Based on the above, this study aims is to analyze the ionic state, form stable compounds with ligands that, in market of enterosorbent pharmaceutical preparations turn, bind and eliminate from the body toxins of and biologically active additives (BAA) registered in the biologically active substances (antigens, histamines, Republic of Uzbekistan and to determine the potential prostaglandins, bilirubin, xenobiotics, etc.), pathogenic for expanding the range of medicinal products and bacteria, and their toxins. BAAs with enterosorbent properties using local natural American Journal Of Biomedical Science & Pharmaceutical Innovation 38 https://theusajournals.com/index.php/ajbspi American Journal of Applied Science and Technology (ISSN: 2771-2745) raw materials with sorptive properties, such as gradually decreasing. As a result, scientists from glauconite. The study will examine the physicochemical various countries are actively researching new and adsorption properties, as well as the promising sorptive materials with a wide range of pharmacological properties of the natural mineral sorptive activity [2, 5]. sorbent glauconite, to develop granulated and Given the above, a promising sorbent with a broad encapsulated enterosorbent forms in the future. spectrum of action is the natural mineral glauconite. METHODS Glauconite (Glauconite) is a potassium-containing The analysis of official sources of information on aluminosilicate with a complex and variable pharmaceutical preparations and biologically active composition (chemical formula - (KNa)(Fe3.AL additives (BAA) registered in the Republic of Uzbekistan Mg)2(SiAl)4O10(OH)2). Glauconite belongs to the [3, 4] was conducted. The object of the study was the group of hydrous micas, a subclass of layered silicates. natural highly dispersed glauconite powder extracted This relatively inexpensive natural mineral has a wide by open-pit mining from the sandstone of the "Changi" range of sorptive activity, high ion-exchange and quarry (Parkent district, Tashkent region, Republic of buffering properties (depending on fractionation from Uzbekistan) and thermally processed to activate it in 200 to 600 μm, the sorptive properties of glauconite the laboratory production conditions of LLC "Fati- range from 20 to 100 mg/g, and after activation using Derm." The thermal activation process was carried out magnetic separation methods, its activity increases by in a laboratory drying oven "SHSU-M1" (Russia) at an additional 45%). A large absorption area was also temperatures ranging from 100 to 300°C, as well as in noted, with the specific sorption surface ranging from a laboratory muffle furnace "MP-2UM" (Vilnius, 0.10 to 0.16 mmol/g depending on the pH of the Lithuania) at temperatures ranging from 400 to 800°C. medium (pH 5.2-7.5). Additionally, the coating Thermogravimetric studies of the sieved fraction of (encapsulating) properties of glauconite were studied. glauconite were conducted using a derivatograph from The sample of glauconite mineral under study is a MOM company in the temperature range of 200-800°C polydisperse powder of a dark olive-green colour, with a heating rate of 10K/min. odorless