Вторичные метаболиты растений рода Scutellaria флоры Узбекистана S. phyllostachya и S. сordifrons: выделение, структура, биологическая активность

Аннотация

of the dissertation is distributed on «___» __________2018. (protocol at the register No _________ dated____________ 2018). V.U.Khujayev Chairman of scientific council on award of scientific degrees, D. Ch.Sc., professor Sh.A.Mamajonov Scientific secretary of scientific council on award of scientific degrees, C. P.Sc.,dosent V.U.Khujayev Chairman of scientific seminar under scientific council on award of scientific degrees, D.Ch.Sc., professor 38 INTRODUCTION (abstract of PhD thesis) The aim of research work is isolation of the flavonoids from plants Scutellaria phyllostachya Juz. and Scutellaria сordifrons Juz., determining their chemical structures and pharmacological properties. The objects of the research work are species of the genus Scutellaria phyllostachya Juz. and Scutellaria сordifrons Juz. Scientific novelty of the research work: 26 flavonoids: 14 glycosides and 12 aglycons from the plants Scutellaria phyllostachya Juz. and Scutellaria сordifrons Juz. have been isolated; it has been determined that 26 substances from the isolated substances belong to the flavones, 2 of them to new flavanones; it has been established, that chemical structures of two new flavanones are -(+)-5,2′- dihydroxy-6,6′,7-trimethoxyflavanone and (+)-5,2′-dihydroxy-6,6′,7,8- tetramethoxyflavanone); Implementation of the research results: Based of the results on the research of flavonoides of four plant species of the genus of Scutellaria L., growing in Uzbekistan: the dissertation has been done, on the basis of scientific projects № 25/98 “Isolation, determination of physiologically active compounds of Scutellaria L plants growing in Ferghana valley” (1999-2001) and № 3.F.3.15 “Studying actions between flavonoids and alkaloids, other pgysiologically active compounds, and investigation of physical-chemical properties of synthesized complexes” (2003-2007) covered by State Committee of Science and Technics. the chemical structure and results of the spectral analyzes of the isolated flavonoids have been used in more than 10 leading international scientific publications to identify and establish the structure of flavonoids (Journal: Fitoterapia, 2010, v. 81. № 6, ResearchGate, IF 1,80; Journal: Chemical & Pharmaceutical Bulletin, 2011, v. 59 № 12, ResearchGate, IF 1,56; Journal: Tetrahedron, 2011, v. 67 № 23, ResearchGate, IF 3,04; Journal: Natural Product Reports. 2011, v. 28. № 10, ResearchGate, IF 12,61; Journal: Natural Product Research, 2014, v. 28 № 7. ResearchGate, IF 0,93; Journal: Tetrahedron Letters, 2016, v. 57. № 30, ResearchGate, IF 2,08; Journal: BMC complementary and alternative medicine, 2017, v. 17. № 431, ResearchGate, IF 2.94 and others). The application of the research results gave possibility to estabilish structures of the isolated flavonoids; published materials on Scutellaria рhyllostachya Juz. and Scutellaria сordifrons Juz were used to analyze chemosystematics of flavonoids of Scutellaria L. plants, in Xinjiang Ethnomedicine Center of Peoples Republic of China (Reference by Xinjiang Ethnomedicine Center, dated on 3rd January 2018). These results made it possible to clarify the structure of flavonoids; published materials on Scutellaria рhyllostachya Juz. and Scutellaria сordifrons Juz were used to analyze flavonoids isolated by Surgut State University (manual of Surgut State University dated on 23rd January 2018). These results made it possible to determine structures of phenolic compounds. The structure and volume of the thesis. The structure of the dissertation consists of an introduction, three chapters, conclusions, list of references and appendices. The text of the thesis consists of 111 pages. 39 ЭЪЛОН ҚИЛИНГАН ИШЛАР РЎЙХАТИ СПИСОК ОПУБЛИКОВАННЫХ РАБОТ LIST OF PUBLISHED WORKS I бўлим (I часть, I part) 1. Siddikov G. U., Yuldashev M. P., Batirov E. Kh., and Abdullaev Sh. V. flavonoids from Scutellaria cordifrons and S. phyllostachya roots // Chemistry of Natural Compounds, Vol. 42, No. 3, 2006 P. 556-357 (02.00.00. №1) 2. Siddikov G. U., Yuldashev M. P., and Abdullaev Sh. V.. Flavonoids from Scutellaria phyllostachya roots // Chemistry of Natural Compounds, Vol. 43, No. 3, 2007 P. 324-325. (02.00.00. №1) 3. Сиддиков Г.У., Мирзахидов Х.А. Scutellaria турига кирувчи айрим ўсимликлар флавоноидларининг бўёқли хусусиятлари. // Кимёвий технология. Назорат ва бошқарув Илмий-техникавий журнал. –Ташкент,2007. № 4 - С.14-17. (02.00.00. №10). 4. Siddikov G. U., Yuldashev M. P., Aripova S. F., Vdovin A. D., Abdullaev N. D., and Botirov E. Kh.. New flavanones from Scutellaria phyllostachya roots // Chemistry of Natural Compounds, Vol. 44, No. 1, 2008 P. 28-30 (02.00.00. №1) 5. Сиддиков Г.У., Абдуллаев Ш.В. Фенольные соединения Scutellaria cordifrons Juz. и Scutellaria phyllostachya Juz.. Вестник НУУз.–Ташкент, 2017. № 2 - С.458-465. (02.00.00. №12). II бўлим (II часть, II part) 1. Сиддиқов Ғ.У., СобировУ. К., Вохидова М., Абдуллаев Ш. В.. // Scutellaria cordifrons Juz. ўсимлигининг флавоноидлари. // Илмий ахборо