METABOLIC SYNDROME IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Аннотация

Goal. To characterize the metabolic syndrome (MT) in patients with SLE and clarify thecontribution ofimmuneinflammation to thedevelopment ofthelatter. Materials and methods. 154 wives were examined. with SLE, MS. age 35 years, duration of the disease 99 months. The control group consisted of 69 people. without rheumatic diseases of comparable age. The APR III criteria were used to diagnose MS. The detection of atherosclerotic vascular lesions was carried out by ultrasound scanning of the carotid arteries. The concentration of cholesterol, TG, and HDL cholesterol in the blood serum was determined by colorimetric and photometricmethods,the levels ofhs-CRPis an immunonephelometricmethod. Results. MS was diagnosed in 29/154 (19%) patients with SLE and in 5/69 (7%) in the control group (p=0.02). The incidence of MS components: hypertension, HTG, and hypoalphalipoproteinemiawas significantly higher in patients with SLE than in thecontrol group. In SLE, the levels of TG, HDL-C, and CRP exceeded the values of these indicators in healthy individuals. The thickness of the carotid artery CMM in SLE and in the control was the same, ATB and coronary artery disease were more often detected in SLE (15% and 14%) than in the control (4% and 2%), (p=0.01). Patients with SLE and MS were older in age, with higher the values of disease activity, IP, and the maximum dose of HC during the disease period (p<0.05). The concentration of CRP was significantly higher in patients with SLE and MS. Subclinical manifestations of atherosclerosis were more often diagnosed in patients SLE and MS compared with patients with SLE without MS (p<0.05). There were no differences in the frequency of detection ofclinical manifestations ofatherosclerosis between thegroups. Conclusion. Autoimmune inflammation in SLE plays an important role in the development of MSand cardiovascular diseases. Key words:autoimmune inflammation, systemic lupus erythematosus, metabolic syndrome, atherosclerosis