ОЦЕНКА ПРОТИВОДИАБЕТИЧЕСКОЙ И ПРОТИВОВОСПАЛИТЕЛЬНОЙ ДЕЙСТВИЯ НЕКОТОРЫХ ЛЕКАРСТВЕННЫХ РАСТЕНИЙ

Аннотация

Pankreatik a-amilaza inhibitörleri R E sifatida noma'lum dorivor xususiyatlarga ega mahalliy V https://orcid.org/0009-0002-0641-2623 IN o'simliklardan foydalanish imkoniyatlari o'rganildi. U Tanlangan 8 ta o‘simlik orasida isiriq, romashka va jasurbeknabiyev865@gmail.com marigoldning 100 mg/ml etanol ekstraktining konsentratsiyasi (80%, 77% va 72% mos ravishda) yuqori inhibitiv faollikka ega ekanligi aniqlandi. Qandli diabetni davolashda ishlatiladigan dorilarning yallig'lanishga qarshi xususiyatlari diabet bilan bog'liq asoratlarni kamaytirishda samarali vosita ekanligi isbotlangan. © N.Q.Nabiyev Shunga ko'ra, isiriq, romashka va marigold o'simliklarining etanol ekstraktining yallig'lanishga qarshi UNIVERSAL xalqaro ilmiy jurnal xususiyatlari o'rganildi. Ushbu o'simliklarning ekstraktlari qizil qon hujayralarining issiqlik bilan ta'minlangan membranasini barqarorlashtirdi. Lavanda 82%, romashka Ochiq ma’lumotlar: 79% va lavanta 85% yallig'lanishga qarshi faollikni https://universaljurnal.uz/index.php/jurnal ko'rsatdi. Shunga ko'ra, bu o'simliklarning ekstraktlari 2- toifa diabetni davolashda istiqbolli hisoblanadi. Maxfiylik bayonoti Kalit so‘zlar. ekstraktlar, inhibisyon, yallig'lanish, Materialni istalgan vosita yoki formatda nusxalash va qayta qizil qon hujayralari, diabet. tarqatish hamda maqoladan toʻgʻri iqtibos keltirish va litsenziyasini koʻrsatish sharti bilan istalgan maqsadda foydalanish mumkin. 40 www.universaljurnal.uz Universal International Scientific Journal 2024, 1(4) Introduction by regulating carbohydrate breakdown and Diabetes mellitus is one of the most glucose absorption in the intestine. Among widespread chronic diseases in the world. It is the white, black, and Oolong teas, the estimated that by 2030, more than 360 million aqueous extract of black tea showed the people will suffer from this disease [1]. The highest α-glucosidase inhibitory activity prevalence of diabetes is higher in Western [5]. countries due to the aging population, physical The secondary metabolites extracted inactivity, and obesity, but it is also spreading from S. persica were studied in vitro for rapidly in developing countries due to their α-amylase inhibitory activity and the progressive urbanization and socio-economic chemical composition responsible for this growth leading to lifestyle changes. activity was determined. The aqueous There are many different therapeutic extract of S. persica inhibited α-amylase approaches for the treatment of type 2 diabetes. activity by 72.39% and showed an IC50 Inhibiting carbohydrate-hydrolyzing enzymes value of 376 μg/ml compared to 65.99% like α-amylase is one of the important inhibition by acarbose [6]. The plant N. approaches to reduce postprandial blood oppositifolia has been used in diabetes glucose levels. Such inhibitors used in clinical treatment. In experiments, 3-oxolupenal practice for diabetes treatment are known to be and katonic acid exhibited IC50 values of associated with various gastrointestinal side 46.2 mg/ml (101.6 mm) and 52.4 mg/ml effects. Therefore, it is necessary to identify α- (119.3 mm) respectively against α- amylase inhibitors from natural sources with amylase, with 3-oxolupenal showing fewer side effects. The aqueous extract of the higher inhibitory activity against α- plant Caesalpinia bonducella inhibited α- glucosidase (62.3 mg/ml or 141.9 mm) amylase activity by 87.26% [2]. The ethanol compared to katonic acid (88.6 mg/ml or extract of Capparis spinosa showed an 194.8 mm) [7]. The root extract of the plant inhibitory effect on α-amylase activity, with Salacia oblonga was phytochemically extracts from the roots and leaves at a examined for its antidiabetic activity, and a concentration of 25 mg/ml inhibiting 97.31– GS-MS analysis was conducted. The total 98.92% of α-amylase [3]. flavonoid, terpenoid, and tannin contents Overweight is a major medical issue that showed inhibitory effects on α-amylase leads to diabetes, cardiovascular diseases, and and α-glucosidase enzymes, with the root metabolic problems. Controlling diet and extract having IC50 values of 73.56 mg/ml physical exercise is fundamental in managing and 80.90 mg/ml for inhibiting α-amylase overweight. The common white bean and α-glucosidase respectively. Fifteen (Phaseolus vulgaris) produces an α-amylase chemical compounds were identified inhibitor, which has been characterized and through GS-MS analysis [8]. The essential tested in many clinical studies [4]. Natural α- oil of Stachys viticina Boiss leaves was amylase and α-glucosidase inhibitors in food evaluated in vitro for its inhibitory products play a key role in controlling properties on microbes, anticancer, postprandial hyperglycemia in type 2 diabetes antioxidant, metabolic enzymes, and 41 UNIVERSAL international scientific journal Universal International Scientific Journal 2024, 1(4) cyclooxygenase (COX). GS-MS analysis with distilled water. The prepared solution identified 52 compounds in S. viticina em. could be u