NEURODEGENERATIVE DISEASES AND THEIR IMPACT ON THE OPTIC NERVE

Аннотация

Study of morphological changes in the central parts of the visual analyzer in glaucoma and identification of the role of mitochondrial dysfunction in the development of neurodegenerative changes. study of morphological changes in the central parts of the visual analyzer in glaucoma and identification of the role of mitochondrial dysfunction in the development of neurodegenerative changes. A post-mortem examination was conducted on two people who had glaucoma during their lives and whose deaths were not associated with diseases of the central nervous system. Immunohistochemical examination revealed astrogliosis and beta-amyloid deposits in the cerebral cortex and optic nerve. Structural and functional changes in mitochondria were detected. Degenerative changes in POAG affect both retinal ganglion cells and optic nerve fibers, as well as tissues of the visual analyzer pathways up to the cerebral cortex. Mitochondrial dysfunction may be one of the mechanisms of development and progression of neurodegeneration in primary open-angle glaucoma.