SOME ASPECTS OF THE MECHANISM OF ANTIPHLOGENIC ACTION OF THE PHYTOCOMPOSITION “LESBOHOL”

Аннотация

; Some mechanisms of the anti-inflammatory action of Lesbohol were studied in experimental animals. It was found that cyclooxygenase inhibition does not play a decisive role in the mechanism of the anti-inflammatory action of Lesbohol. Removal of the adrenal glands clearly reduces the anti-inflammatory activity of Lesbohol associated with the suppression of glucocorticoid secretion. Lesbohol suppresses the level of pro-inflammatory cytokines (IL-1-β and TNF-α) and increases the level of anti-inflammatory cytokine (IL-10). Suppression of the kinin system and a decrease in vascular permeability are important factors in the anti-inflammatory action of Lesbohol. It is believed that the mechanism of anti-inflammatory activity ofLesbohol is largely duetoitsantioxidant property. Key words: phytocomposition, vascular permeability, kinin system, cyclooxygenases, pro- andanti-inflammatory cytokines, free radical processes. Conflict of interest. The authors declare no obvious or potential interests related to the publicationof thisarticle.